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27-34 Of note, several trials in the PIONEER program used two estimands to further distinguish their analyses: 1) a treatment-policy estimand, which used data collected at the end of the study period (e.g., week 26 or 52) in the analysis regardless of treatment discontinuation or use of rescue medication

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[DOI] [PMC free article] [PubMed] [Google Scholar] 66.Salameh T.S., Rhea E.M., Talbot K., Banks W.A

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